A brief introductory video explaining Micropore's unique membrane-based system
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The smallest unit in the Micropore range of crossflow micromixing devices, is winning fans worldwide.
The Micropore AXF Mini is a starting point for formulating using crossflow membrane technology, or for low volume production runs to continuously manufacture of up to 20L/hr of mono-dispersed formulations.
Offering the same tightly controlled particle size precision that is a feature of all Micropore's crossflow devices. The Micropore AXF-mini system incorporates a precision engineered tubular membrane. In simple terms the shear required for droplet formation is generated from the flow of the continuous phase through the device.
In the case of making mRNA vaccines or, indeed, any other RNA product the critical parameter is the ability to control the mixing of a formulation of, typically, four lipids in solution with the mRNA in a buffer solution without damaging the delicate mRNA.
Operating at low pressure (requiring typically 85% lower energy than alternative technologies), independent research at the University of Strathclyde in Scotland lead by Dr Yvonne Perrie has demonstrated that, Micropore’s membrane-based crossflow devices deliver no detectable degradation to mRNA, which is widely acknowledged to be very sensitive to energy inputs. This is an exciting result for vaccine manufacturers because it demonstrates that crossflow membrane mixing could open the door to the cost-efficient mass production of a whole new generation of LNP-based therapeutics.
The AXF-mini’s 316 electropolished stainless steel body, with ergonomic triclamps (rather than push-fit or screwed) connections, allows for easy sterilisation. With no moving parts, it is an elegant, robust and easy to maintain device for continuously manufacturing high quality emulsions The internal tubular membrane is precision engineered with laser drilled pores along its length, allowing for the manufacture of near mono-dispersed particles/droplets (CV in the range 12-15%).
Phase concentration of up to 40% and more
All Micropore equipment uses precision engineered stainless steel membranes. These membranes provide:
In this application the membrane is used to control the degree of micromixing to enable precise self-assembly (in the case of liposomes or Lipid nanoparticles (LNPs), or to control solvent exchange (in the case of crystallisation).
In this application of Micropore’s technology the membrane is used to control the size of microspheres and microcapsules produced by providing a gentle shear force to deform and detach the droplets as they form through the pores.
Larger throughput Micropore XF equipment can be specified and set-up using data generated on the Micropore AXF-Mini. This allows production to be readily scaled up to a manufacturing process offering:
Micropore works closely with clients to optimise particle size and performance in their formulations. We have a full product offering from lab, through development and pilot scale to full scale manufacturing. Results generated in the lab with Micropore equipment are directly scalable to full scale manufacturing in contract with most scale-up regimes.
FORMULATION DEVELOPMENT WITH MICROPORE
At Micropore we enjoy working in partnership with our clients to solve formulation challenges and deliver the highest performing, most sustainable, most cost-effective formulated delivery systems.
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